A biochemistry graduate specializing in amyloidosis, synthesis of neuroprotective nanomaterials, cell culture, and animal models. Recognized for punctuality, strong problem-solving, proactive approach, creativity, and leadership skills. I'm an adaptable team player with a positive attitude, eager to leverage my research background to drive breakthroughs in healthcare, particularly in the realm of neurodegenerative diseases
Analytical chemistry techniques:
UV-Vis
Fluorescence
FTIR
CD
DLS
AFM
Cell culture techniques:
Aseptic technique
Media preparation
Cell seeding and passaging
MTT assay
LDH Assay
Wound healing assay
Fluorescence microscopy:
Fluorophore labeling
Image processing and analysis
Live cell imaging techniques
Ligand binding assay
Protein expression and purification:
Expression induction and optimization
Cell lysis and protein extraction
Chromatography
Gel electrophoresis:
SDS-PAGE
Native PAGE
Imaging techniques:
MRI
PET
SPECT
Animal models and in vivo experiments:
Animal housing and care
Administration of treatments or interventions
Tissue sample collection
Implanting tumors
Design and synthesis of nanoparticles for drug delivery and imaging applications:
Metal nanoparticles
Polyphenols-based nanoparticles
Polymeric nanoparticles
Graphene oxide nanosheets
· S. Jalili, M. Panji, M. Mahdavimehr, A. Mohseni Ahangar, H. Shirzad, S.A. Mousavi Nezhad, F.L. Palhano, Enhancing anti-amyloidogenic properties and antioxidant effects of Scutellaria baicalensis polyphenols through novel nanoparticle formation, Int. J. Biol. Macromol. 262 (2024). https://doi.org/10.1016/j.ijbiomac.2024.130003.
· E.R. Ghareghozloo, M. Mahdavimehr, A.A. Meratan, N. Nikfarjam, A. Ghasemi, B. Katebi, M. Nemat-Gorgani, Role of surface oxygen-containing functional groups of graphene oxide quantum dots on amyloid fibrillation of two model proteins, PLoS One 15 (2020) 1–19. https://doi.org/10.1371/journal.pone.0244296.
· M. Mahdavimehr, B. Katebi, A.A. Meratan, International Journal of Biological Macromolecules Effect of fi brillation conditions on the anti-amyloidogenic properties of polyphenols and their involved mechanisms, Int. J. Biol. Macromol. 118 (2018) 552–560. https://doi.org/10.1016/j.ijbiomac.2018.06.109.
· B. Katebi, M. Mahdavimehr, A.A. Meratan, A. Ghasemi, M. Nemat-Gorgani, Protective effects of silibinin on insulin amyloid fibrillation, cytotoxicity and mitochondrial membrane damage, Arch. Biochem. Biophys. 659 (2018) 22–32. https://doi.org/10.1016/j.abb.2018.09.024.
· M. Mahdavimehr, A.A. Meratan, M. Ghobeh, A. Ghasemi, A.A. Saboury, M. Nemat-Gorgani, Inhibition of HEWL fibril formation by taxifolin: Mechanism of action, PLoS One 12 (2017) 9–11. https://doi.org/10.1371/journal.pone.0187841.
Poster
· Amyloidogenic conditions may dramatically bias antiamyloidogenic properties of polyphenols, 3rd National Conference on Protein and Peptide Sciences, April 25 & 26, 2018, Shiraz.
· Investigating the anti-Amyloidogenic and antioxidant properties of novel natural polyphenol-based nanoparticles. 1th conference on modern biotechnology. August 29 & 30, 2023, Tehran.
Oral talk
· Improvement of Breast tumor Imaging by Multifunctional SPION Nanoparticles Conjugated with a Novel Engineered Endostatin Peptide, 6th Annual International TPCF Preclinical Imaging Symposium, November 8 & 9, 2023, Tehran
· Accomplished climber
· Adventurous tracker
· Leisure swimmer
· Passionate weekend chef
Dr. Ali Akbar Meratan: Associate Professor of Biochemistry; PhD.
Tel: (+98) 24 3315 3309,
Email: a.meratan@iasbs.ac.ir