Debananda Gogoi
Dublin
Summary
A committed academic professional with a Ph.D. in Molecular Biology & Biotechnology and more than 10 years of experience in translational research, specializing in biologics characterization, method validation, and regulatory compliance. Experienced in teaching and leading cross-functional teams. Passionate about undergraduate education, I am seeking the position of Lecturer at RCSI, where I can apply my research expertise and teaching background to contribute to the development of innovative medical curricula, deliver high-quality education, and enhance student engagement through dynamic, creative teaching methods.
Overview
12
12
years of professional experience
1
1
Certification
Work History
Senior Postdoctoral Research Scientist
Royal College of Surgeons Ireland
10.2021 - Current
- Conducted independent and collaborative research adhering to the highest ethical standards, both within RCSI and beyond.
- Made original contributions to immunobiology and chronic airway disease research, specifically in COPD, AATD, and CF.
- Led pioneering studies on complement (C3) and P2 purinergic receptor signaling in respiratory diseases, advancing understanding of these conditions.
- Collaborated with multidisciplinary teams to identify biomarkers and explore novel treatments for chronic inflammatory diseases.
- Investigated ER stress in monocytes and hepatocytes, exploring cellular responses and associated pathophysiology.
- Managed administrative and program-related tasks associated with the research projects.
- Supervised and mentored research graduates, students, and junior team members in the Principal Investigator’s group.
- Contributed to the dissemination of research findings through academic papers, conference presentations, and engagement with professional networks.
- Managed sensitive patient samples and ensured secure and accurate data handling.
- Participated in training and development to enhance transferable skills and career progression.
- Authored and co-authored scientific papers, including data analysis and literature review.
Postdoctoral Research Associate
University of Virginia
10.2020 - 04.2021
- Conducted experiments, analyzed results, and contributed to the design of antibodies for ovarian cancer and cell culture procedures.
- Participated in project planning and development of research protocols, ensuring adherence to scientific principles and federal guidelines.
- Coordinated literature reviews, summarized findings, and developed derivative applications of research techniques. Presented research at local, national, and international scientific meetings.
- Composed and reviewed articles for publication in scientific journals.
- Supervised and coordinated research activities of students, graduate assistants, and research personnel.
- Calibrated, maintained, and instructed others on microscopes, analytical equipment, and other scientific tools.
- Advised the principal investigator and research team on techniques, procedures, and research-related technologies.
Guest Faculty & Project Scientist
National Institute of Technology
10.2018 - 08.2020
- Deliver undergraduate teaching in immunology and biochemistry, integrating bioassay methodologies to enhance laboratory competency and align with industry standards.
- Coordinate and design course content and assessment materials in line with the latest developments in biochemistry.
- Develop and implement innovative teaching methods, including technology-enhanced learning strategies.
- Supervised laboratory sessions, ensuring hands-on skill development in enzyme kinetics and electrophoresis.
- Support students’ development through mentoring and offering additional learning resources.
- Collaborate with academic colleagues to enhance the quality of the curriculum and ensure student success.
- Participate in the development and revision of teaching programmes and contribute to quality assurance/quality improvement activities.
- Designed and assessed student assignments and facilitated group discussions.
Senior Research Fellow
Tezpur University
10.2016 - 06.2018
- Executed analytical testing and method validation for solid/liquid formulations, drug substances, and raw materials using UV/VIS spectroscopy, dissolution studies, and chromatography techniques.
- Developed cost effective, novel antithrombotic anticoagulant herbal drug and standardized its biomarker assisted quality control.
- Responsible for delivering scientific insights and translating in vitro and pre-clinical findings, as well as designing experimental protocols.
- Spearheaded and conducted SDS-PAGE, ELISA, qPCR, Western blot and interventional studies to assess the efficacy and stability of protein therapeutics, ensuring data integrity and regulatory compliance.
Project Fellow
Tezpur University
12.2012 - 03.2014
- Optimized purification strategies for biopharmaceuticals using chromatography and electrophoresis, improving yield, purity, and batch-to-batch consistency for therapeutic applications.
- Implemented stability studies, evaluating the impact of temperature, pH, and excipients on protein integrity to ensure formulation robustness and regulatory compliance.
Education
Ph.D. - Molecular Biology & Biotechnology
Tezpur University
Tezpur, India12.2019
M.Sc. - Biotechnology
Vellore Institute of Technology
Vellore, India06.2012
B.Sc. - Biotechnology, Microbiology & Chemistry
M.S. Ramaiah College of Arts, Science & Commerce
Bangalore, India05.2010
Skills
- Teaching & Curriculum Development: Design/delivery of undergraduate courses, case-based tutorials, and lab sessions
- Research & Scholarship: Published research lung inflammation (AATD, CF, ILD) with a commitment to advancing knowledge in respiratory science
- Student Engagement: Mentored 15 postgraduate scholars; trained interns in lab techniques and critical thinking
- Technology-Enhanced Learning: Proficient in LMS platforms, statistical tools, and innovative teaching methodologies
- Communication & Collaboration: Strong interpersonal skills, evidenced by multidisciplinary teamwork and stakeholder engagement
- Time Management & Organization: Skilled in balancing teaching responsibilities with research and administrative tasks
- Professional Development: Strong commitment to ongoing learning and professional growth, particularly in educational methods and research skills
Certification
- Research Animal Training, LAST Ireland, 2025
- Lean Six Sigma Green Belt, Kennesaw State University, USA (Coursera Online), 2025
- Good Laboratory Practice, National Institute of Technology, India, 2019
- Advanced HPLC & Mass Spectroscopy Techniques, Tezpur University, India, 2016
Accomplishments
- Published 18 peer-reviewed articles and secured 01 patent.
- Trained and mentored 15+ postgraduate, Ph.D. scholars, and research assistants.
- Reduced laboratory investigations turnaround time by 30% through process optimization.
- Successfully led 07 research projects, ensuring on-time delivery and regulatory compliance.
- Best Poster Award, RCSI Research Day (2023) for innovative findings in immunology and translational research.
- Recipient of the 2023 ERS-CF Travel Bursary, awarded for contributions to research in chronic respiratory diseases.
- Translational Research Award (2022), Beaumont Hospital recognizing excellence in applying research to real-world therapeutic solutions.
- Best Oral Presenter Award, Natural Product Research, India (2017) for outstanding presentation on biopharmaceutical advancements.
- DBT-BIRAC Fellowship (2016) awarded for contributions to biotechnology and pharmaceutical research.
- Tezpur University Institutional Fellowship (2014) in recognition of academic excellence and research contributions.
- Secured €0.6M in research funding as a co-applicant from US Alpha 1 & Cystic Fibrosis Foundations, RCSI StAR MD, and Pfizer Educational Project Grants.
Affiliations
- Irish Thoracic Society
- European Respiratory Society
- American Thoracic Society
Additional Information
Publications in International Peer Reviewed Journals.
1. Gogoi, D., Yu, H., Casey, M., Baird, R., Yusuf, A., Forde, L., ... & Reeves, E. P. (2024). Monocyte NLRP3 inflammasome and interleukin-1β activation modulated by alpha-1 antitrypsin therapy in deficient individuals. BMJ Thorax.
2. Forde, L., Gogoi, D., Baird, R., McCarthy, C., Keane, M. P., Reeves, E. P., & McGrath, E. E. (2024). Does ATP via purinergic receptor signalling fuel pulmonary fibrosis?. Journal of Innate Immunity, 1-14.
3. Baird, R., Yusuf, A., Forde, L., Pohl, K., Kavanagh, K., Fitzpatrick, F., ... Gogoi, D., & Reeves, E. P. (2024). The vacuolar anti-Pseudomonal activity of neutrophil primary granule peptidyl-arginine deiminase enzymes. Frontiers in Immunology, 15, 1452393.
4. Gogoi, D., Chattopadhyay, P., Dolui, S. K., Khan, M. R., & Mukherjee, A. K. (2024). Studies on in vivo antithrombotic activity of quercetin, a natural flavonoid isolated from a traditional medicinal plant, African eggplant (Solanum indicum). Journal of Ethnopharmacology, 335, 118686.
5. Lacey, N., Teo, J. Y., Baird, R., Forde, L., Hawkins, P., McEnery, T., ... Gogoi, D., & Reeves, E. P. (2024). Augmentation Therapy Decreases Platelet-Neutrophil Aggregates in Alpha-1 Antitrypsin Deficiency. American Journal of Respiratory Cell and Molecular Biology, 70(6), 524-527.
6. Das, M. J., Banerjee, D., Banerjee, A., Muchahary, S., Sinha, A., Gogoi, D., ... & Deka, S. C. (2024). Safety and antidiabetic activity of Lagenaria siceraria (Molina) Standl. juice in streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, 319, 117111.
7. McEnery, T., White, M. M., Gogoi, D., Coleman, O., Bergin, D., Jundi, B., ... & Reeves, E. P. (2022). Alpha-1 antitrypsin therapy modifies neutrophil adhesion in patients with obstructive lung disease. American Journal of Respiratory Cell and Molecular Biology, 67(1), 76-88.
8. Caird, R., Williamson, M., Yusuf, A., Gogoi, D., Casey, M., McElvaney, N. G., & Reeves, E. P. (2022). Targeting of glycosaminoglycans in genetic and inflammatory airway disease. International Journal of Molecular Sciences, 23(12), 6400.
9. O’Brien, M. E., Murray, G., Gogoi, D., Yusuf, A., McCarthy, C., Wormald, M. R., ... & Reeves, E. P. (2022). A review of alpha-1 antitrypsin binding partners for immune regulation and potential therapeutic application. International Journal of Molecular Sciences, 23(5), 2441.
10. Fee, L. T., Gogoi, D., O’Brien, M. E., McHugh, E., Casey, M., Gough, C., ... & Reeves, E. P. (2021). C3d elicits neutrophil degranulation and decreases endothelial cell migration, with implications for patients with alpha-1 antitrypsin deficiency. Biomedicines, 9(12), 1925.
11. Gogoi, D., Jha, S., Chattopadhyay, P., & Mukherjee, A. K. (2020). A simple, cost‐effective, and rapid separation process for the isolation of anticoagulant active fraction from the fruit extract of Momordica charantia: Characterization of bioactive components and anticoagulant mechanism of active fraction in a mouse model. Journal of Separation Science, 43(20), 3902-3912.
12. Gogoi, D., Ramani, S., Bhartari, S., Chattopadhyay, P., & Mukherjee, A. K. (2019). Characterization of active anticoagulant fraction and a fibrin (ogen) olytic serine protease from leaves of Clerodendrum colebrookianum, a traditional ethno-medicinal plant used to reduce hypertension. Journal of ethnopharmacology, 243, 112099.
13. Gogoi, D., Pal, A., Chattopadhyay, P., Paul, S., Deka, R. C., & Mukherjee, A. K. (2018). First report of plant-derived β-sitosterol with antithrombotic, in vivo anticoagulant, and thrombus-preventing activities in a mouse model. Journal of natural products, 81(11), 2521-2530.
14. Bora, B., Gogoi, D., Tripathy, D., Kurkalang, S., Ramani, S., Chatterjee, A., & Mukherjee, A. K. (2018). The N-terminal-truncated recombinant fibrin (ogen) olytic serine protease improves its functional property, demonstrates in vivo anticoagulant and plasma defibrinogenation activity as well as pre-clinical safety in rodent model. International journal of biological macromolecules, 111, 462-474.
15. Gogoi, D., Arora, N., Kalita, B., Sarma, R., Islam, T., Ghosh, S. S., ... & Mukherjee, A. K. (2018). Anticoagulant mechanism, pharmacological activity, and assessment of preclinical safety of a novel fibrin (ogen) olytic serine protease from leaves of Leucas indica. Scientific reports, 8(1), 6210.
16. Gogoi, D., Bhagowati, P., Gogoi, P., Bordoloi, N. K., Rafay, A., Dolui, S. K., & Mukherjee, A. K. (2016). Structural and physico-chemical characterization of a dirhamnolipid biosurfactant purified from Pseudomonas aeruginosa: application of crude biosurfactant in enhanced oil recovery. RSC advances, 6(74), 70669-70681.
17. Dutta, S., Gogoi, D., & Mukherjee, A. K. (2015). Anticoagulant mechanism and platelet deaggregation property of a non-cytotoxic, acidic phospholipase A2 purified from Indian cobra (Naja naja) venom: inhibition of anticoagulant activity by low molecular weight heparin. Biochimie, 110, 93-106.
18. Majumdar, S., Sarmah, B., Gogoi, D., Banerjee, S., Ghosh, S. S., Banerjee, S., ... & Mukherjee, A. K. (2014). Characterization, mechanism of anticoagulant action, and assessment of therapeutic potential of a fibrinolytic serine protease (Brevithrombolase) purified from Brevibacillus brevis strain FF02B. Biochimie, 103, 50-60.
Book Chapter:
- Gogoi, D., Yusuf, A., Baird, R., McElvaney, N.G., Casey, M., Reeves, EP Animal models to study inflammation and infection in CF, 2024| European Cystic Fibrosis Society book Inflammation & Infection in Cystic Fibrosis, chapter 9, pg 137-148
Under Communication
- A review of Proteases and Antiprotease for Immune Regulation and Potential Therapeutic Application in Pulmonary Fibrosis. Journal of Innate Immunity
- CFTR modulator therapy impacts neutrophil CD39 expression in cystic fibrosis. American Journal of Respiratory Cell and Molecular Biology
Publication in International/National Conferences
1. Gogoi, D. Faisal., A., Baird, R., Forde, L., Ahmed, S., Niu, M., Reeves, E. (2025). The impact of MZB1 protein expression in immune and hepatic cells in AATD. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.2025.211.Abstracts.A3479
2. Gogoi, D., Casey, M., Bolger, C., Alghamdi, S., Acquilini, P., D’Costa, L., ... & Reeves, E. (2023). CFTR Modulator Therapy Rescues CFTR and Lowers P2X7R-induced Inflammasome Activation of Airway Epithelial Cells. ERJ Open Research 9 (suppl 12)
3. Baird, R., Gogoi, D., Yusuf, A., Murray, G., Murphy, M., Casey, M., & Reeves, E. (2023). Peptidyl-arginine deiminases–neutrophil derived proteins as anti-Pseudomonas aeruginosa agents in patients with cystic fibrosis. ERJ Open Research 9 (suppl 10)
4. Gogoi, D., Casey, M., Yusuf, A., Gabillard-Lefort, C., Gunaratnam, C., McElvaney, N. G., & Reeves, E. P. (2022, December). Decreased anti-neutrophil cytoplasmic autoantibodies (ANCA) against bactericidal/permeability-increasing (BPI) post CFTR modulator therapy. in Irish Journal Of Medical Science (vol. 191, pp. s160-s161).
5. Yusuf, A., Casey, M., Gogoi, D., Gabillard-Lefort, C., Gunaratnam, C., McElvaney, N. G., & Reeves, E. P. (2022, December). The CFTR modulator combination elexacaftor/tezacaftor/ivacaftor restores CFTR protein expression in circulating neutrophils of patients with cystic fibrosis. in Irish Journal Of Medical Science (Vol. 191, pp. S160-S160).
6. Gogoi, D.,Casey, M., Yusuf, A., Fraughen, D., Herron, M., Alhaddah, L., ... & Reeves, E. P. (2022, December). Inhibition of C3d signalling downregulates NLRP3 inflammasome activation and IL-1 beta production in monocytes of individuals with alpha-1 antitrypsin deficiency. in Irish Journal Of Medical Science (Vol. 191, pp. S173-S173).
7. Baird, R. D., Gogoi, D., Yusuf, A., Casey, M., Murray, G., Murphy, M., & Reeves, E. P. (2022, December). Investigating peptidyl-arginine deiminases as novel antimicrobial agents against bacterial pathogens of patients with cystic fibrosis. in Irish Journal Of Medical Science (Vol. 191, pp. S160-S160).
8. Yusuf, A., Gogoi, D., Gabillard-Lefort, C., Gunaratnam, C., McElvaney, N. G., Casey, M., & Reeves, E. P. (2022, December). Circulating soluble P2X7 receptor as a novel indicator of resolution of inflammation in patients with cystic fibrosis. in Irish Journal Of Medical Science (Vol. 191, pp. S184-S185).
9. Gogoi, D.,Fee, L. T., O’Brien, M. E., Murphy, M., Hopkins, A., Carroll, T. P., ... & Reeves, E. P. (2022). C3d Triggers Neutrophil Degranulation And Decreases Endothelial Cell Migration, with Implications for Patients with Alpha-1 Antitrypsin Deficiency. in B21. Basic, Clinical, And Translational Copd Studies: The Ongoing Hunt For Underlying Mechanisms And Therapeutic Targets (pp. A2415-A2415). American Thoracic Society.
Granted Patent
- Anticoagulant actives and synergistic anticoagulant composition and method for producing the same. Inventor: Ashis Kumar Mukherjee and Debananda Gogoi. Patent number - 427825 · Granted Mar 30, 2023
Research Funding
- Exploring the Role of MZB1 in Alpha-1 Antitrypsin Deficiency and Disease Pathogenesis
US Alpha 1 Foundation, May 2025, $150000
Principal Investigator
- StAR MD Programme 2024- Cathepsin Protease Activity in Idiopathic Pulmonary Fibrosis
RCSI, 3 May 2024, €150000
Co- Applicant
- Exploring Pro-resolving Lipid Complexes to Realize the Full Therapeutic Impact of Alpha-1
Alpha-1 Foundation (US), 19 May 2023 - 30 September 2024, €75000
Co- Applicant
- StAR MD Programme 2023- Purinergic Signalling In Interstitial Lung Disease
RCSI, 23 Jan 2023, €150000
Co-Applicant
- Student Selected Projects (SSP) 2023
RCSI, 5 Jan 2023, € 2000
- The impact of CFTR modulation on plasma biomarkers of P. aeruginosa infection
Strategic Partnership Pfizer Healthcare Ireland, 19 July 2022- 30 September 2023, € 20000
Co-Applicant
- Student Selected Projects (SSP) 2022
RCSI, 16 May 2022, € 2000
- Development of a cost effective, novel antithrombotic anticoagulant herbal drug and standardization of its biomarker assisted quality control, INR 4750000
BIRAC-DBT India, 16 October 2016- 15 October 2018
BIRAC/IKP0333/BIG-08/16 to AKM
References
1. Prof. Emer Reeves
Department of Anesthesia & Critical Care
Royal College of Surgeons in Ireland
Email id: emerreeves@rcsi.ie
2. Dr. Bhaskarjyoti Gogoi
Department of Biotechnology
Royal Global University, Assam
Email Id: gogoi.bhaskar2608@gmail.com
Timeline
Senior Postdoctoral Research Scientist
Royal College of Surgeons Ireland
10.2021 - Current
Postdoctoral Research Associate
University of Virginia
10.2020 - 04.2021
Guest Faculty & Project Scientist
National Institute of Technology
10.2018 - 08.2020
Senior Research Fellow
Tezpur University
10.2016 - 06.2018
Project Fellow
Tezpur University
12.2012 - 03.2014
Ph.D. - Molecular Biology & Biotechnology
Tezpur University
M.Sc. - Biotechnology
Vellore Institute of Technology
B.Sc. - Biotechnology, Microbiology & Chemistry
M.S. Ramaiah College of Arts, Science & Commerce
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